Hyperbaric Oxygen Therapy Shows Promise for Reducing Disease Activity in Hospitalized Ulcerative Colitis Patients
Outcome This phase 2B randomized trial demonstrates that hyperbaric oxygen therapy (HBOT) at 2.4 atmospheres for 90-minute sessions significantly improves disease activity in hospitalized patients with moderate to severe ulcerative colitis (UC) flares. By Day 3 a 55% response rate was noted characterized by reductions in stool frequency rectal bleeding and C-reactive protein (CRP) levels. […]
Lower-Dose Hyperbaric Oxygen Therapy Shows Superior Results in Early Stage Traumatic Brain Injury Recovery
Outcome This study reveals that hyperbaric oxygen therapy (HBOT) at 1.6 ATA (atmospheres absolute) significantly improves neural functional recovery in rats with traumatic brain injury (TBI). The research demonstrated that 1.6 ATA HBOT reduces the expression of extracellular histones H1 H2A and H4 as well as inflammatory cytokine NF-κB leading to decreased apoptosis in peri-lesioned […]
HBOT Shows Promise in Reducing Inflammatory Pain and Neuroinflammation
Outcome This study demonstrates that hyperbaric oxygen therapy (HBO) can be an effective treatment for reducing inflammation-related pain. The research showed that both seven daily 60-minute HBO treatments and five daily 60-minute HBO treatments significantly reduced heat hyperalgesia mechanical allodynia and paw edema in animal models. Such treatments also attenuated neuroinflammation marked by reduced activation […]
Hyperbaric Oxygen Therapy Alters Over 8000 Genes Boosting Cell Protection and Repair
Outcome This study reveals that hyperbaric oxygen therapy (HBOT) at 2.4 atmospheres significantly regulates over 8100 genes in human microvascular endothelial cells (HMEC-1). Key genes such as immediate early transcription factors (FOS FOSB JUNB) and metallothioneins exhibited notable responses both immediately and 24 hours post-treatment. The research underscores the role of the Nrf-2 oxidative stress […]
Hyperbaric Oxygen Therapy Significantly Reduces Inflammatory Markers in Keloid Patients
Outcome This study highlights the significant impact of hyperbaric oxygen (HBO) therapy on inflammatory factors in keloid tissues. It was observed that keloid tissues exhibit markedly higher levels of inflammatory mediators such as IL-12p40 MIP-1β PDGF-BB and IL-1Ra when compared to normal skin samples. The application of HBO therapy resulted in distinct changes in these […]
Hyperbaric Oxygen Therapy Enhances Brain Healing and Reduces Inflammation After Traumatic Brain Injury
Outcome The study illustrates the significant neuroprotective effects of hyperbaric oxygen (HBO) therapy on traumatic brain injury (TBI) in mice. Administered at 2.0 absolute atmosphere (ATA) with 100% oxygen HBO therapy was shown to boost both serum and cerebral levels of the anti-inflammatory protein Interleukin-10 (IL-10). This increase in IL-10 was associated with a reduction […]
Hyperbaric Oxygen Therapy Significantly Improves Skin Conditions in Children with Severe Atopic Dermatitis
Outcome Hyperbaric Oxygen Therapy (HBOT) significantly improved the skin condition of children with severe atopic dermatitis after a 30-day treatment as measured by the SCORAD and oSCORAD scales. Reductions in skin lesions redness swelling oozing/crusting scratch marks and skin lichenification were observed. Patients also reported less itching and better sleep quality. A notable decrease in […]
Hyperbaric Oxygen Therapy Brings Relief to Long-Standing Complex Regional Pain Syndrome
Outcome The case study demonstrates that hyperbaric oxygen therapy (HBOT) can significantly benefit individuals with long-standing complex regional pain syndrome (CRPS). The patient showed substantial improvement in CRPS symptoms which allowed for a drastic reduction in prednisone dosage to near-physiological levels mitigating steroid-related complications. Introduction Complex Regional Pain Syndrome (CRPS) is a challenging and debilitating […]
Lower Pressure Oxygen Treatment More Effective for Inflammatory Gene Expression in Chronic Wounds Study Finds
Outcome This study examined how different pressures of hyperbaric oxygen therapy (HBOT) affect the expression of inflammatory genes in human endothelial cells. It was found that a lower pressure of 1.5 atmospheres absolute (atm abs) led to more significant changes in gene expression compared to a higher pressure of 2.4 atm abs. Introduction This study […]
Hyperbaric Oxygen Therapy Shows Promise for Treatment of Severe Inflammatory Bowel Disease Reports Significant Improvement
Outcome The outcomes of the systematic review indicate that hyperbaric oxygen therapy (HBOT) shows significant potential in treating inflammatory bowel disease (IBD) specifically Crohn’s disease and ulcerative colitis. Both human and animal studies demonstrate that HBOT substantially reduces inflammation and oxidative stress which are central to IBD pathology. Introduction Traditionally used for conditions such as […]