Outcome

The case report on Hyperbaric Oxygen Therapy (HBO2) demonstrates significant enhancements in both cognitive performance and physical health markers. Following a rigorous protocol of 60 HBO2 sessions at 2 ATA over three months the study showed marked improvements ranging from 3.1% to 3.8% in global cognitive functions and all cognitive domains.

Introduction

Hyperbaric Oxygen Therapy (HBO2) has gained attention as a potential intervention for improving cognitive and physical performance. This case report explores the effects of HBO2 therapy over 60 sessions each conducted at two absolute atmospheres (ATA) for 100 minutes spanning three months. The subject experienced significant improvements in global cognitive function with a 3.1–3.8% increase across various cognitive domains. Advanced neuroimaging techniques including MRI perfusion and SPECT scans revealed substantial enhancements in cerebral perfusion ranging from 43.3–52.3% and 8.79–16.12% respectively in brain regions vital for memory coordination and visual-motor functions. Additionally MRI-DTI scans indicated increased white matter integrity particularly in the corpus callosum and fornix.

Physical assessments also showed marked benefits with improvements of 7–15% in metrics such as anaerobic threshold exercise endurance muscle strength gait speed and grip strength. Notably telomere length—an indicator of cellular aging—doubled and clusters of inflammatory proteins decreased around the 40th session and remained low by the 60th session. These findings suggest that HBO2 therapy could significantly enhance cognitive and physical performance reduce inflammation and potentially slow cellular aging. Further larger-scale studies are necessary to validate these promising results and understand their long-term implications.

Results

Neurocognitive testing demonstrated a 3.1–3.8% improvement in global cognitive function and all cognitive domains. Advanced imaging studies provided further insights with MRI perfusion scans revealing a 43.3–52.3% increase in cerebral blood flow in areas associated with memory coordination and visual-motor cortex function. SPECT scans also showed an 8.79–16.12% increase in perfusion in key memory-related regions including the temporal pole entorhinal cortex subcallosal area and lingual gyrus.

MRI-DTI scans indicated significant enhancements in white matter integrity; fractional anisotropy increased by 9% in the corpus callosum 16.85% in the fornix and 22.06% in the tapetum. Physical health markers also showed marked improvement with a 7–15% increase in anaerobic threshold exercise endurance muscle strength gait speed and grip strength.

One of the most notable findings was the doubling of telomere length a marker linked to cellular aging and longevity. Additionally clusters of inflammatory proteins which were initially present began to decrease around the 40th session and remained low by the 60th session.

These results from a single subject suggest that Hyperbaric Oxygen Therapy (HBO2) can significantly enhance cognitive performance cerebral blood flow white matter integrity and physical capabilities while also reducing inflammation and potentially impacting cellular aging positively.

Conclusion

In conclusion this single-subject case report on Hyperbaric Oxygen Therapy (HBO2) indicates substantial benefits across multiple health dimensions. Sixty sessions of HBO2 at 2 ATA over three months resulted in noteworthy improvements in cognitive performance enhanced cerebral perfusion and increased white matter integrity. Additionally significant gains were observed in various physical performance metrics alongside a marked reduction in inflammatory proteins and a doubling of telomere length suggesting potential anti-aging effects.

These preliminary findings highlight the efficacy of HBO2 in enhancing both brain function and physical capabilities—a promising avenue for therapies targeting cognitive decline physical endurance and cellular aging. To corroborate these results and understand their long-term implications further studies involving larger cohorts and controlled clinical trials are essential. Future research should also explore the underlying mechanisms of these observed benefits to expand the clinical applications of HBO2. This case report sets the stage for robust investigations into the therapeutic potential of hyperbaric oxygen therapy.